December 31, 2003

Some People Never Learn

As I was browsing through my e-mail last Saturday, a title leapt out at me. "You're famous again for being wrong!"

Odd way to start a letter, but then I saw who it was from, and all was clear. Yep, Mike Fumento sent me a Christmas card.

For those who weren't around last summer, Mike and I went a couple of rounds on SARS and the Atkins Diet, culminating in a rather spectacular meltdown by Mike, as documented here.
I excerpted a couple of the choicer insults and posted them over to the left as an ironic trophy, then forgot the whole thing.

Until Saturday.

Here's what he wrote:

Hey Rich,

SARS and your know-it-all attitude have come back to haunt you. See the bottom of this column.

http://www.fumento.com/disease/fluanxiety.html

Of course, I realize that to a true blue blogger such as you any traffic is good traffic. But to those of us who occupy the real world and not the blogosphere, looking like an idiot is not a pleasant experience. So while you bathe in the glory of increased hits, other people are going to be laughing their heads off at your "East Tennessee perspective."

Have a nice day!

Sincerely,
Michael Fumento

Oh, and don't bother trying to yank your comments from your archives. I made a snapshot. Your shots that fell on your own bow are part of history!

Now, everybody knows I enjoy a good dustup, so I went over to Mike's place to read his latest column, and found that once again, he gets it wrong. The main thrust of Mike's argument is that this current flu season is serious, but not that big of a deal, and is being overhyped by the media and the CDC, a standard Fumento target. But, as usual, his argument is filled with misleading information, selective citations, and a disregard for facts.

He starts by claiming that the CDC has "arbitrarily" declared the flu an epidemic, and then defines epidemic as "higher than usual rate." This definition is fine as far as it goes, but he leaves out an important part; time. As his provided link shows, an epidemic is a higher than expected number of cases during a given time. This is crucial to our understanding of what an epidemic is, and whether or not the current flu season qualifies.

For example, 10 deaths of flu in a large town in January might not be considered an epidemic. The same number deaths in June would be. The CDC classifies an epidemic not just by number of deaths, but by when they occur as well.

Next Fumento hauls out a graph from the CDC, and claims that it shows that this season is the same as the 1999-00 season, and therefore there is not an epidemic. This comparison fails for a number of reasons.
fluchart.gif

First, as you look at the chart, you see that the flu season started much earlier this year, and that flu rates are running as much as 500% higher than the same time last year, and 250% higher than the same time for the 1999-00 flu season.

Next, we see that the shape of the curve is different. Comparing 1999-00 to 2003-04, the curves are diverging. The rate of increase in flu cases is higher now than in 1999-00.

Next, even though we are about 2 weeks ahead of the 1999-00 peak, we've already exceeded that peak by about 0.3%. I know that seems small, but it becomes important in a minute.

Finally, we have to discuss the overall shape of the curves. Note the sharp drop in the 1999-00 curve. That drop is the result of two factors. First, the vulnerable population is limited, and unless the strain is particularly virulent, exhausted fairly quickly in a large outbreak. Second, vaccinations begin to take hold, reducing the vulnerability of the general population. This year, as Mike points out, the vaccine will be only partially effective in preventing this year's dominant strain. Not only did this contribute to the early start to the season, it also means that we can expect a more gradual tapering of the rate of increase of new cases, rather than the sharp drop we've seen in the past.

So, let's add up these factors. The dominant strain is a Type A strain, one of the more virulent; the vaccine is only partially effective at limiting the spread of the flu; supplies of the vaccine are, for all intents and purposes, exhausted; and we've already observed more cases and higher rates of infection when compared to the last Type A flu outbreak. Take these factors together and you have a strong case for predicting an epidemic.

In fact, the article Mike cites spells it out for us.

The number of deaths caused by pneumonia and influenza is just under a statistically determined "epidemic threshold." But, she (Julie Gerberding, director of the Centers for Disease Control and Prevention) said, from a practical standpoint, "it's safe to call it an epidemic."

Now, let's go to the CDC, and see what the most recent numbers are.

fluchart2.gif
Looking at this chart, you can see several interesting things. First, the curve has broken, showing that while the rate at which new flu cases are reported is still increasing, the rate of that increase has slowed. Also, you can see that we haven't peaked yet, and that the peak will be significantly higher than 1999-00. And finally, you can see that the break is nowhere near as sharp as 1999-00, which indicates that the rate of flu may continue to increase for a few more weeks, instead of dropping off sharply, leading to a significantly higher number of cases. My prediction has been born out by the actual numbers.

But is it an epidemic?

Well, there's one more chart we need to look at; the mortality rate chart. This one tells us whether we are in an actual epidemic or not, not arbitrarily, but by statistical analysis of deaths related to flu/pneumonia.
mort.gif
A couple of quick observations about the chart. Note that the seasonal norm and the epidemic level vary over time and track with each other. That's why it's important to include time in the definition of epidemic, and why Mike's contention that the 1999-00 chart and this year's chart are identical is bogus.

Now, look closely at the last weeks of 2003. You can see that last week we were rapidly approaching epidemic levels, and this week, we crossed it. Based on the information we had, it was fairly easy to predict that this would happen, and it wasn't arbitrary at all, as Mike suggests.

But we really need to look at one more thing, something that shows just how wrong Mike is. Mike is telling us that there is no epidemic because the current curve is tracking the 1999-00 curve, but the 1999-00 curve resulted in epidemic flu conditions for most of a year! Look at the other end of the curve, for weeks 0-20 of 2000. The mortality due to flu peaked at 11.3%, well above the epidemic levels, and remained above the seasonal norms for most of the year, spending a significant amount of time above epidemic levels, even during the summer months. Add in the factors we've discussed for this year, the early start to the season, the weakened ability of the vaccine to protect against infection, and the fact that we're already exceeding 1999-00 levels and the only reasonable prediction to make is that this season will be significantly worse than 1999-00.

In other words, an epidemic.


PS: My mail program marked the e-mail from Mike as spam.

Smart program.

Posted by Rich at December 31, 2003 12:01 AM | TrackBack
Comments

So, is it TERRORISM! or what?

Maybe you should reconsider having a blog category called "science".

Posted by: SKB on December 31, 2003 1:01 AM

Regarding your assertion that the flu season hasn't yet peaked, that conclusion is not supported by the second chart.

Since the points only show level and not rate, it's impossible to tell whether the last point is still on the increasing side of the curve or whether the peak occured between the last two points and the last point is merely higher up on the decreasing side.

We won't know until next month's data comes out.

Posted by: Stormy Dragon on December 31, 2003 11:01 AM

Stormy, technically, you are correct. It is possible, though highly unlikely, that the peak occurred midweek, and we are on the downside. However, this is not a random phenomena, where we can't make predictions based on previous observations. Based on those observations, namely the shape of curves from previous years, and the relatively short (weekly) sampling period, it is possible that week 51 was the peak, but it is most likely that the peak is still to come.

On the other hand, going from a mathematical point of view, for our purposes we don't have to calculate the exact derivative to determine the rate of increase in infections; identifying the points of inflection and estimating from there works just fine. On that basis, it is safe to say that the rate of increase has not peaked yet.

Saying we won't know until the next data set is released is true, just like saying that we won't know if the sun will come up tomorrow until dawn is also true.

But I'd put money on either of them.

Posted by: rich on December 31, 2003 11:47 AM

My reason for thinking so is that the in the two other years shown don't slow down significantly before hitting the peak.

The other thing I note is there appears to be an inverse relationship between severity and duration of the flu outbreak; the worse it is, the sooner it ends.

Posted by: Stormy Dragon on December 31, 2003 1:14 PM

The inverse relationship is directly related to the limited size of the at-risk population I referred to in the post. The harder the bug hits, the faster it races through the pool of vulnerable people, which means it tends to die out quicker, unless it's a strain that affects a wider range of people. Even though the Type A strain is stronger than most, it is still relatively common, so most folks will have some immunity to it.

I see your point about the sharp peaks of the previous years, but I believe the moderate drop is due to the relative weakness of the available vaccine leading to a less dramatic drop in the rate of increase.

But, as you say, this is speculation, and we won't know who is correct until we get a couple more data points.

Take care.

Posted by: rich on December 31, 2003 3:14 PM

Gee Rich, that was swell! I like how you completely avoided the thrust of my comment, that whatever the flu season is doing this year it completely blows SARS out of the water. Specifically, flu is on track to kill its usual 36,000 Americans this year while the SARS epidemic over which you promoted hysteria managed to kill fewer than 800 people WORLDWIDE.

In any case, once again you ended up shooting off lots of rounds right into the water. As an article from WebMD posted today as I write this (Dec. 31)shows (http://my.webmd.com/content/article/79/96056.htm?z=1728_00000_1000_nb_05), only now MIGHT we reached an "epidemic threshold." Which is to say that I was completely right in my column of Dec. 25th in which I stated, "Flu may become epidemic, but it's not yet."

but wait, there's more! According to the San-Diego Union-Tribune ("http://www.signonsandiego.com/news/metro/20031231-9999_6m31flu.html), again of December 31, "This year, the flu has hit 46 states, prompting CDC to say it is nearing epidemic levels." Sorry Rich, but "nearing" is not "at." So even the CDC is wavering on whether it's epidemic, but Rich Haley, in all his epidemiological wisdom, is a better spokesman for the CDC than the CDC.

Finally, despite my own assertion about your shells missing, one claim of yours did blow me out of the water in the sense of flabbergasting me. You claim that flu having started earlier contributes to your position. What hooey! Flu doesn't begin on a given day like Christmas. It's always earlier or later than average. That has nothing to do with epidemic levels.

Keep growing that beard, Rich, and crawl back into that spider hole!

Michael Fumento

Posted by: Michael Fumento on December 31, 2003 5:38 PM

From the CDC data linked in my post comes the following statement:

"During week 51, 7.8% of all deaths reported by the vital statistics offices of 122 U.S. cities were due to pneumonia and influenza. This percentage is at the epidemic threshold of 7.8% for week 51."

Rather than go to secondary sources, since we all know how often reporters get things wrong, I went to the primary source, the CDC, to get my data, and the primary source says plainly that the flu is at an epidemic level.

And the contention that timing has no impact on what levels would be considered epidemic simply ignores reality. The mortality chart produced by the CDC quite clearly shows that the level of infection defined as epidemic varies over time, based on deviation from a seasonal baseline compiled from historical data.

As for SARS and promoting hysteria, the reader is invited to take a look through my archives and try to find any such statements. Just go to the search window and type in SARS. You'll find several pieces on SARS, including one where I said this:
"My problem with Fumento is he was arguing that the reaction to the SARS outbreak was driven by greed, not any genuine concern, and that SARS was a minor problem."

And later this:
"I'm guessing overall mortality will wind up in the 8-9% range, which is significant for modern times, but as long as SARS remains relatively non contagious, will keep it from becoming the next plague."

Yep, that's promoting hysteria all right.

And on a personal note, I'm not allowed to grow a beard. It would interfere with the seal on my respirator.

Posted by: rich on January 1, 2004 3:15 AM

Regarding SARS, you're right I did say SARS was a minor problem. Fewer than 800 deaths worldwide compared to an average of 36,000 flu deaths annnually in the U.S. alone is a minor problem. End of story. And while I didn't predict it, the dearth of SARS cases so far this season does add to my case.

Regarding flu being epidemic, below is from today's CNN.com. You'll note that even as it says the outbreak is on the decline it also says, "it's not certain if this flu season will be more severe than past outbreaks." In other words, there's STILL no evidence it ever actually reached epidemic threshold. Yes, I know the CDC has gone back and forth on this, but just as they exaggerated AIDS and SARS they also felt the obligation to exaggerate flu for the same reason -- they felt it necessary to bring more attention to the problem. The CDC is a political animal and has been since it made the leap with AIDS. You just fell for it because, as with SARS, you're operating way outside your league. Again, leave the epidemiology to the experts. And cozy up that spider hole.

CDC: Flu outbreak on decline

(CNN) --Influenza activity appears to be on the downturn in the United States, even as federal officials report more than 90 children have died of the flu this season.

The Centers for Disease Control and Prevention said that 38 states still had widespread activty, down from 42 reported previously.

So far, 93 children under the age of 18 have died of the flu this season, with about 60 percent of them under 5 years old. Whether this number is comparable to past outbreaks is hard to tell, the CDC said. The agency normally doesn't track children's flu deaths so no firm figures for the past exist.

The CDC said that further studies on the impact flu has on children were in development, as well as ways to determine risk factors for severe illness and hospitalization.

This year's outbreak began earlier than usual and has spread more widely than usual, but it's not certain if this flu season will be more severe than past outbreaks, or if it just peaked early. On average, flu kills about 36,000 people in the United States each year.

Before the new CDC numbers were released, Dr. Anthony Fauci -- director of the National Institute of Allergy and Infectious Diseases -- said that the flu season's severity and length is never predictable, but there are some signs to look for.

"When you see states that have widespread activity, when they start to turn the corner, then you have a pretty good indication that we're going in the right direction," he said on CNN's "American Morning."

The especially virulent strain of the virus that is predominant this season was not included in this year's flu vaccine. Fauci said efforts were being made to remedy that and to develop new ways of making the vaccine.

"That's the thing that from the research standpoint we are working on very diligently right now," Fauci explained. "Of developing new types of approaches, of being able to quicken and give greater efficiency to the process of being able to identify the strain and getting it into the vaccine in time."



Find this article at:
http://www.cnn.com/2004/HEALTH/01/08/sprj.flu03.flu/index.html

Posted by: Michael Fumento on January 8, 2004 2:00 PM

With a significant drop for week 1 of 2004, it looks even more likely that the peak was between those last two data points.

Do I get a cookie? ;>

Posted by: Stormy Dragon on January 8, 2004 7:22 PM

Sorry stormy, but no cookie. Check out this post for the story straight from the CDC.

As you can see from those charts, week 51 showed the first decrease, where you speculated that the peak may have been between weeks 50-51. In week 52 the flu rate soared, so the peak could not have been between weeks 50 and 51. Since I wrote that post this afternoon, they've updated the link to show week 53, which shows the sharp decrease Fumento is bragging about.

What's cool is that this year's curve looks to be showing the same thing you noticed earlier, that intensity and duration of an outbreak are indirectly proportional.
Take care

Posted by: rich hailey on January 8, 2004 11:52 PM

No cookie? Curses, foiled again!

Posted by: Stormy Dragon on January 9, 2004 10:26 AM
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